Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
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چکیده
منابع مشابه
Role of microRNA-134 in the neuroprotective effects of propofol against oxygen-glucose deprivation and related mechanisms.
This study is to investigate the effects of propofol on primary hippocampal neurons under oxygen-glucose deprivation (OGD) condition and related mechanisms. The apoptotic process was detected with flow cytometry, and the cell viability was assessed with CCK-8 assay. The expression levels of microRNA (miRNA)-134 were detected with quantitative real-time PCR. Protein expression levels were detect...
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Article is available under a Creative Commons license; see publisher's site for details.
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OBJECTIVES To reveal the effect of microRNA-210 on cell apoptosis caused by HIE. METHODS Postnatal day 7 rats after HI injury were intraventricularly injected with microRNA-210 mimic, microRNA-210 inhibitor, or physiological saline. 72 h after the injection, rats were sacrificed and the left hemispheres were collected. The expression level of microRNA-210 was identified by quantitative real-t...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2012
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.2834